Nanocurcumin Promising Candidate for Therapeutic Applications

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Nanocurcumin Promising Candidate for Therapeutic Applications ( nanocurcumin-promising-candidate-therapeutic-applications )

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Edited by: Jun Lu, Auckland University of Technology, New Zealand Reviewed by: Constantin Mircioiu, Carol Davila University of Medicine and Pharmacy, Romania Fabiola Paciello, Catholic University of the Sacred Heart, Italy Guozheng Huang, Xinjiang Technical Institute of Physics & Chemistry (CAS), China *Correspondence: Taesun Min tsmin@jejunu.ac.kr Specialty section: This article was submitted to Drug Metabolism and Transport, a section of the journal Frontiers in Pharmacology Received: 25 January 2020 Accepted: 27 March 2020 Published: 01 May 2020 Citation: Karthikeyan A, Senthil N and Min T (2020) Nanocurcumin: A Promising Candidate for Therapeutic Applications. Front. Pharmacol. 11:487. doi: 10.3389/fphar.2020.00487 1 Subtropical Horticulture Research Institute, Jeju National University, Jeju, South Korea, 2 Department of Plant Molecular Biology and Bioinformatics, Center for Plant Molecular Biology and Biotechnology, Tamil Nadu Agricultural University, Coimbatore, India, 3 Faculty of Biotechnology, College of Applied Life Science, Sustainable Agriculture Research Institute (SARI) and Jeju International Animal Research Center (JIA), Jeju National University, Jeju, South Korea Curcuma longa is an important medicinal plant and a spice in Asia. Curcumin (diferuloylmethane) is a hydrophobic bioactive ingredient found in a rhizome of the C. longa. It has drawn immense attention in recent years for its variety of biological and pharmacological action. However, its low water solubility, poor bioavailability, and rapid metabolism represent major drawbacks for its successful therapeutic applications. Hence, researchers have attempted to enhance the biological and pharmacological activity of curcumin and overcome its drawbacks by efficient delivery systems, particularly nanoencapsulation. Research efforts so far and data from the available literature have shown a satisfactory potential of nanorange formulations of curcumin (Nanocurcumin), it increases all the biological and pharmacological benefits of curcumin, which was not significantly possible earlier. For the synthesis of nanocurcumin, an array of techniques has been developed and each technique has its own advantages and individual characteristics. The two most popular and effective techniques are ionic gelation and antisolvent precipitation. So far, many curcumin nanoformulations have been developed to enhance curcumin delivery, thereby overcoming the low therapeutic effects. However, most of the nanoformulation of curcumin remained at the concept level evidence, thus, several questions and challenges still exist to recommend the nanocurcumin as a promising candidate for therapeutic applications. In this review, we discuss the different curcumin nanoformulation and nanocurcumin implications for different therapeutic applications as well as the status of ongoing clinical trials and patents. We also discuss the research gap and future research directions needed to propose curcumin as a promising therapeutic candidate. Keywords: curcumin, Curcuma longa, diferuloylmethane, nanoformulation, turmeric REVIEW published: 01 May 2020 doi: 10.3389/fphar.2020.00487 Nanocurcumin: A Promising Candidate for Therapeutic Applications Adhimoolam Karthikeyan1, Natesan Senthil2 and Taesun Min3* Frontiers in Pharmacology | www.frontiersin.org 1 May 2020 | Volume 11 | Article 487

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