Electroanalytical dsDNA and curcumin vs copper

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Electroanalytical dsDNA and curcumin vs copper ( electroanalytical-dsdna-and-curcumin-vs-copper )

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Electroanalytical study of the interaction between dsDNA and curcumin in the presence of copper(II) C. Serpi1, Z. Stanić 2, S. Girousi 1* 1Laboratory of Analytical Chemistry, Department of Chemistry, Aristotle University, Thessaloniki 54124, Greece 2 Department of Chemistry, Faculty of Sciences, University of Kragujevac, R.Domanović 12, P.O. Box 60, 34000 Kragujevac, Serbia Abstract As a result of the reaction between curcumin (CC) and copper(II) the characteristic peak of curcumin at -1.0 V significantly increased, and the peak at -1.6 V disappeared. Curcumin forms complex with copper(II). The interaction between double stranded (ds) calf-thymus DNA and curcumin in the presence of Cu(II) was studied in solution, by differential pulse adsorptive transfer voltammetry using carbon paste electrode (CPE) and hanging mercury drop electrode (HMDE). Cu(II)-CC complex generated changes in calf thymus DNA. The characteristic peak of dsDNA, due to the oxidation of guanine residues, decreased. The increased DNA damage by Cu(II)-CC complex was observed in the presence of various concentrations of the transition metal ions, copper(II). Keywords: DNA interaction; Curcumin; Copper(II); Carbon paste electrode * Corresponding author: e-mail: girousi@chem.auth.gr (S. Girousi) , tel:+30-2310-997722, fax:+30-2310-997719 1 Introduction 1

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